• "A very interactive collaboration with LifeTec Group has, within a few months, resulted in very exciting results. The data will hopefully be the basis for future collaborative activities focused on improving bone quality and the healing of fractures."

    J. Gossen PhD
    CEO

The quest

Nowadays there are many people with cartilage and bone defects or diseases. Consequently various treatment options are being developed in industrial and academic settings. In the phase of pre-clinical testing only cell-based approaches and animal trials were available to assess performance of potential therapies. The information obtained from cell-based studies is limited as the setting is very simplified, e.g. lack mechanical conditioning, and does not represent the 3D in vivo environment. On the other hand, animal trials are costly, elaborate, and require a lot of animals.

 

  • LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
  • LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
  • LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
  • LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
  • LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
  • LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform
    LifeTec Group | Osteochondral Platform

The platform

LifeTec Group recognized this hiatus in the preclinical research field and that is why the company developed a ex vivo osteochondral platform that is representative for the in vivo situation. The throughput platform consists of viable and functional osteochondral biopsies, which can be (mechanically) conditioned and monitored in a controlled manner, allowing for cost-efficient long-term assessment of regenerative cartilage and bone therapies.

With the osteochondral platform LifeTec Group is able to assess the effect of newly developed biomaterials, pharmaceuticals, implant devices or combinations thereof on cartilage and bone response and repair. The model is typically used instead of animal studies as a screening tool for testing arrays of different material compositions, implant coatings and drug dose-response studies. Based on these studies, the most promising candidates are selected for the next steps in the pre-clinical phase. This way, our clients can significantly reduce the number of animals needed and save time, effort and money. 

Please do not hesitate to contact Linda Kock if you require any further information:

Project Leader
Linda Kock
Call at +31 (0)40 298 93 93 or e-mail us

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