Scientific Paper - Preface

Nowadays there are many people with cartilage and bone defects or diseases. Consequently various treatment options are being developed in industrial and academic settings. In the phase of pre-clinical testing only cell-based approaches and animal trials were available to assess performance of potential therapies. The information obtained from cell-based studies is limited as the setting is very simplified, e.g. lack mechanical conditioning, and does not represent the 3D in vivo environment. On the other hand, animal trials are costly, elaborate, and require a lot of animals.

Scientific Paper - Introduction

Many people suffer from cartilage degeneration due to genetic abnormalities, trauma, or osteoarthritis.

One of the main issues in this regard is that articular cartilage possesses limited regeneration ability because of its avascular character and the fact that only one cell type (chondrocytes) is present.

Articular cartilage is central to the proper functioning of synovial joints. It covers the opposing articulating bones, and through its properties of high resiliency and deformability, it protects them from compressive joint loads. It provides a smooth and gliding surface with a very low coefficient of friction.

Because of the absence of self-repair abilities, various surgical interventions and biomaterials have been explored to facilitate regeneration of cells and cartilaginous matrix.

Osteoarthritis - Knee
"clinical treatments are limited"

The purpose of surgery is the regeneration of the chondral defects to ultrastructural and biomechanical competent hyaline cartilage.

From a scientific point of view, the clinical treatments are limited in their ability to functionally regenerate cartilage defects, as they often result in the formation of fibrotic tissue, which consists mainly of collagen type I and is therefore mechanically inferior to native cartilage.

Therefore, in a collaborative effort within the BIOGEL network to solve the aforementioned problems, a novel hydrogel with promising characteristics for functional cartilage repair has been tested in a relevant 3D tissue model: the Osteochondral Platform of LifeTec Group.

----------------------------------------------------------------------------------------------------

“Cartilage Regeneration in Preannealed Silk Elastin-like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform." 

by Mr. Filippo Cipriani, Melanie Krüger*, Israel González de Torre, Luis Quintanilla, Matilde Alonso, Linda Kock*, José Carlos Rodríguez-Cabello

  • Technical Proteins Nanobiotechnology S.L., Paseo Beleń 9A, 47001 Valladolid, Spain 
  • (*) LifeTec Group, Kennedyplein 10-11, 5611 ZS Eindhoven, The Netherlands 
  • Bioforge, University of Valladolid CIBER-BNN, Paseo de Beleń 19, 47001 Valladolid, Spain

----------------------------------------------------------------------------------------------------

Investigating treatments for Cartilage and Bone defects and diseases (Scientific Paper)
Scientific Paper - Abstract

Tissue engineering for cartilage repair requires
 biomaterials that show rapid gelation and adequate mechanical properties. Although the use of hydrogel is the most
 promising biomaterial, it often lacks in rigidity and anchorage
of cells when they are surrounded by synovial fluid while they
are subjected to heavy loads.  We developed and produced the
 Silk Elastin-Like co-Recombinamer (SELR), which contains
 both the physical interaction from elastin motifs and from silk
 motifs.   

Read more / download paper >> 

Please do not hesitate to contact Melanie Krüger if you require any further information:

Biochemical Engineer
Melanie Krüger
Call at +31 40 298 93 93 or e-mail us

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642687

Colofon
Biogel

Relevant links and background information:

Comments

It is so great to see this collaboration of several groups of people, each with their own research but both with the same ultimate goal: to help people get better health! Using a novel simulation platform to study a novel therapy as well as the tissue response, leading towards a new cure. Compliments to everyone involved!

Leave a message!

©2018 LifeTec Group.  Legal  Credits